Diastereoselective Synthesis of trans-?-Lactams Using a Simple Multifunctional Catalyst

Ciby J. Abraham; Daniel H. Paull; Cajetan Dogo-Isonagie; Thomas Lectka

doi:10.1002/chin.200944111

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Journal article

Diastereoselective Synthesis of trans-?-Lactams Using a Simple Multifunctional Catalyst

Ciby J. Abraham, Daniel H. Paull, Cajetan Dogo-Isonagie and Thomas Lectka

ChemInform, Vol.40(44), pp.no-no

11-03-2009

DOI: https://doi.org/10.1002/chin.200944111

Abstract

azetidine derivatives

cycloaddition reactions

diastereoselective syntheses

enantioselective syntheses (incl. cis/trans-isomerism)

A catalytic, highly diastereoselective process for the synthesis of trans-β-lactams is reported. This system is based on a phosphonium fluoride precatalyst that both activates the nucleophile and directs the reaction process for high yield and diastereoselectivity.

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Title: Diastereoselective Synthesis of trans-?-Lactams Using a Simple Multifunctional Catalyst
Creators: Ciby J. Abraham - Johns Hopkins University
Daniel H. Paull - Johns Hopkins University
Cajetan Dogo-Isonagie - Johns Hopkins University
Thomas Lectka - Johns Hopkins University
Publication Details: ChemInform, Vol.40(44), pp.no-no
Publisher: WILEY-VCH Verlag
Number of pages: 1
Identifiers: 99383442237406570
Academic Unit: Department of Chemistry & Physics
Language: English
Resource Type: Journal article

Diastereoselective Synthesis of trans-?-Lactams Using a Simple Multifunctional Catalyst

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