Abstract
Excerpt: Cerebrovascular reactivity (CVR) refers to the responsiveness of cerebral vasculature to vasoactive stimuli, and reflects vascular reserve information. Hemodynamic changes represented in CVR metrics precede and contribute to neuropathology, and change in response to interventions, such as revascularization in steno-occlusive disease.1 CVR impairments have been associated with a range of disorders including stroke, brain tumors, traumatic brain injury, substance abuse, multiple sclerosis, hypertension, diabetes, small vessel disease, cardiovascular disease, and dementia.2, 3 The relationship of CVR with normal aging, toward quantification of neural activity, cognition, as well as mild cognitive impairment in the general population is of interest.2, 4
