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Effects of human mesenchymal stem cells on ER-positive human breast carcinoma cells mediated through ER-SDF-1/CXCR4 crosstalk.
Journal article

Effects of human mesenchymal stem cells on ER-positive human breast carcinoma cells mediated through ER-SDF-1/CXCR4 crosstalk.

Lyndsay Rhodes, James W. Antoon, Shannon E. Muir, Steven Elliott, Barbara S. Beckman and Matthew E. Burow
Molecular Cancer
11-18-2010

Abstract

Conditioned Medium Transwell Migration Assay CXCR4 Signalling Human Breast Adenocarcinoma Cell Line Endocrine Therapy Resistance Breast--Cancer.
Adult human mesenchymal stem cells (hMSC) have been shown to home to sites of carcinoma and affect biological processes, including tumour growth and metastasis. Previous findings have been conflicting and a clear understanding of the effects of hMSCs on cancer remains to be established. Therefore, we set out to investigate the impact of hMSCs on the oestrogen receptor positive, hormone-dependent breast carcinoma cell line MCF-7.
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https://doi.org/10.1186/1476-4598-9-295View

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