MicroRNA regulation of mammalian target of rapamycin expression and activity controls estrogen receptor function and RAD001 sensitivity.
Lyndsay Rhodes, Elizabeth C. Martin, Steven Elliott, Adrienne E. Krebs, Kenneth P. Nephew, Erik K. Flemington, Bridgette M. Collins-Burow and Matthew E. Burow
The AKT/mammalian target of rapamycin (mTOR) signaling pathway is regulated by 17α-estradiol (E2) signaling and mediates E2-induced proliferation and progesterone receptor (PgR) expression in breast cancer.