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Microwave-Promoted Alkynylation-Cyclization of 2-Aminoaryl Ketones: A Green Strategy for the Synthesis of 2,4-Disubstituted Quinolines
Journal article   Peer reviewed

Microwave-Promoted Alkynylation-Cyclization of 2-Aminoaryl Ketones: A Green Strategy for the Synthesis of 2,4-Disubstituted Quinolines

Iraj Mohammadpoor-Baltork, Shahram Tangestaninejad, Majid Moghadam, Valiollah Mirkhani, Salma Anvar and Arsalan Mirjafari
Synlett, Vol.2010(20), pp.3104-3112
12-15-2010

Abstract

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Abstract A series of 2,4-disubstituted quinolines were easily prepared through a one-pot reaction of structurally diverse 2-aminoaryl ketones with various arylacetylenes in the presence of K 5 CoW 12 O 40 ˙3H 2 O as a reusable and environmentally benign catalyst under microwave irradiation and solvent-free conditions.

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