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Modelling periodic oscillations during somitogenesis
Journal article   Open access   Peer reviewed

Modelling periodic oscillations during somitogenesis

Peng Feng and Menaka Navaratna
Mathematical biosciences and engineering : MBE, Vol.4(4), pp.661-673
10-2007
PMID: 17924717

Abstract

Animals Basic Helix-Loop-Helix Transcription Factors - biosynthesis Basic Helix-Loop-Helix Transcription Factors - genetics Biological Clocks - genetics Biological Clocks - physiology Gene Expression Regulation, Developmental Models, Genetic Numerical Analysis, Computer-Assisted RNA, Messenger - biosynthesis RNA, Messenger - genetics Somites - embryology Zebrafish - embryology Zebrafish - genetics Zebrafish Proteins - biosynthesis Zebrafish Proteins - genetics
We consider a model of genetic network that has been previously presented by J. Lewis. This model takes the form of delay differential equations with two delays. We give conditions for the local stability of the non-trivial steady state. We investigate the condition under which stability is lost and oscillations occur. In particular, we show that when the ratio of the time delays passes a threshold, sustained oscillations occur through a Hopf bifurcation. Through numerical simulations, we further investigate the ways in which various parameters influence the period and the amplitude of the oscillations. In conclusion, we discuss the implications of our results.
url
https://doi.org/10.3934/mbe.2007.4.661View
Published (Version of record) Open

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