Abstract
Various nitro/nitrile-functionalized benzimidazol-2-ylidene carbene complexes of silver(I) (7a-d and 11a-d) were synthesized by combination of 1-allyl/1-isopropyl/1-sec-butyl/1-isopentyl-3-(nitro/cyano-benzyl)-3H-benzimidazol-1-ium hexafluorophosphate (6a-d and 10a-d) with silver(I) oxide in acetonitrile. The compounds were characterized by H-1, C-13 NMR, FT-IR, mass spectrometry, and elemental analysis. Additionally, the in vitro antibacterial activity of the N-heterocyclic carbene (NHC) precursors (6a-d and 10a-d) and their corresponding NHC-silver(I) complexes (7a-d and 11a-d) were investigated against Gram-positive bacteria Staphylococcus aureus and Gram-negative bacteria Escherichia coli using the qualitative Kirby-Bauer disk diffusion method. All the NHC-silver(I) complexes exhibited medium-to-high antibacterial activity with areas of clearance ranging from 12mm to 21mm, while the NHC precursors were inactive against both strains of bacteria.
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