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Optimization of single-base-pair mismatch discrimination in oligonucleiotide microarrays
Journal article   Peer reviewed

Optimization of single-base-pair mismatch discrimination in oligonucleiotide microarrays

Hidetoshi Urakawa, Said El Fantroussi, Hauke Smidt, James C Smoot, Erik H Tribou, John J Kelly, Peter A Noble and David A Stahl
Applied and environmental microbiology, Vol.69(5), p.2848
05-01-2003

Abstract

Chemical reaction, Rate of DNA microarrays Environmental aspects Genetic aspects Microbiology Nucleic acids Nucleotides Oligomers Physiological aspects Ribosomal RNA
Research has been conducted on oligonucleiotide DNA microarrays. The discrimination between target RNA or target DNA and single-nucleotide-mismatch variants has been investigated via the use of nonequilibrium dissociation kinetics to produce the optimum washing temperature in order to study this discrimination.

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