Abstract
Here, a well-known antibacterial cationic branched polyethyleneimine (PEI) is used as organic linker in the preparation of metal organic frameworks (MOFs) with a lanthanide salt, Cerium (III) nitrate (Ce(NO3)(3)) for two types of MOFs. One of the MOF is PEI-Ce(III) prepared from the aqueous solutions of PEI and Ce (III) ions at room temperature. The second MOF is prepared from the HCl treated PEI (p-PEI) and Ce(NO3)(3) in ethanol as p-PEI-Ce (NO3)(3) MOFs. The MOFs are prepared at 1: 0.25, 1:0.5 and 1:1 mol ratios of PEI repeating unit to Ce(III) ions and named as p-PEI-Ce(NO3)(3)-0.25,-0.5, and-1, respectively. The prepared PEI-Ce(III) MOFs are in powder form, whereas p-PEI-Ce(NO3)(3) MOFs are sticky and viscous as gum and soluble in water. The surface areas of PEI-Ce (III) MOFs are found to decrease with the increase in the amount Ce(III) amount and maximum surface area is measured for PEI-Ce(III)-0.25 as 142.3 m(2)/g, while the surface area of p-PEI-Ce(NO3)(3) MOFs cannot be measured. Additionally, all the PEI-Ce(III) MOFs are found blood compatible with < 0.5% hemolysis and > 90% blood clotting index values up to 0.25 mg/mL concentration. Also, the antioxidant activity of PEI which is 1107 +/- 26 Trolox Equivalent Antioxidant Capacity (TEAC mM/g) is retained as 166 +/- 12, 186 +/- 1.0, 194 +/- 2.0 for pPEI-Ce(NO3)(3)-0.25,-0.5, and-1 MOFs, respectively whereas no antioxidant activity in for Ce(III) is measured at the same concentrations. More importantly, the antimicrobial activity of PEI that is measured by via both micro-dilution and disc diffusion antimicrobial tests is also maintained for p-PEI-Ce(NO3)(3) MOFs against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus aureus, and Candida albicans with the MIC values ranging 0.625-5.0 mg/mL and the MBC values of 1.25-10 mg/mL.
