Abstract
PURPOSE: Phaisma B-type natriuretic peptide (BNP) levels obtained at lest have been previously shown to be correlated with the global functional capacity measures of peak oxygen uptake (Vo(2peak)) and the minute ventilation/carbon dioxide (VE/Vco(2)) slope T -lie purpose of this study was to assess the relationship of the plasma BNP level to the rate-pressure product (RPP) as an indicator of central or cardiac work capacity
METHODS: Twenty-two Subjects (12 men)., mean age 5 7 12 yearn, diagnosed with heart failure, (8 ischemic/14 nonischemic) were recruited All Subjects were stable on optimal medical therapy for at least I month Blood samples for SNP level analysis were obtained at lest subjects underwent a symptom-limited treadmill exercise lest g a ramping protocol while Vo(2) heart rate, (HR), and blood pressure Sure (BP) were monitored Correlation analyses were conducted to assess the relationship of BNP level to RPP level, Vo(2peak), VE/VCO2, slope, end-tidal CO2, pressure (PETCO2), and left. ventricular ejection fraction (LVEF)
RESULTS: Resting BNP levels were significantly correlated with RPP levels (r = -0 69) The BNP level and the RPP level were correlated with Vo(2peak) (r = -0 63 and r = 0 66, respectively) and VE/VCO2)., slope (r = 0 53 and r = -0 54, respectively) The RPP level but not the BNP level was correlated with PETCO2 (i = 0 57) Neither BNP nor RPP levels were well correlated with LVEF (r = -0 26 and r = 0.14, respectively)
DISCUSSION: The results Of thin, study suggest that resting plasma BNP level may be a useful clinical measure for evaluating both global functional capacity and myocardial specific work capacity in individuals with heart failure