Abstract
The isolation and structure elucidation of two cyclic peptides, pahayokolides A (
1
) and B (
2
), is described. Structural features determined for these compounds include a pendant
N
-acetyl-
N
-methyl leucine, both
E
- and
Z
-dehydrobutyrines, a homophenylalanine, and an unusual polyhydroxy amino acid that is most likely of mixed polyketide synthase/nonribosomal peptide synthase origin. These peptides were purified from a new species of cyanobacteria of the genus
Lyngbya
, which was isolated from a periphyton mat from the Florida Everglades.