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Three‐Component Coupling Reactions of Silyl Glyoxylates, Vinyl Grignard Reagent, and Nitroalkenes:  An Efficient, Highly Diastereoselective Approach to Nitrocyclopentanols.
Journal article

Three‐Component Coupling Reactions of Silyl Glyoxylates, Vinyl Grignard Reagent, and Nitroalkenes: An Efficient, Highly Diastereoselective Approach to Nitrocyclopentanols.

Greg Boyce and Jeffrey S. Johnson
Angewandte Chemie International Edition
10-14-2010

Abstract

A regio‐ and stereoselective three‐component coupling reaction generates functionalized (Z)‐silyl enol ethers through a vinylation/[1,2]‐Brook rearrangement/vinylogous Michael reaction cascade. These adducts can then undergo a diastereoselective deprotection/intramolecular Henry sequence to rapidly assemble densely functionalized nitrocyclopentanols with three contiguous stereocenters (see scheme; TES=triethylsilyl).
url
https://doi.org/10.1002/anie.201003470View

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