Travel surveillance uncovers dengue virus dynamics and introductions in the Caribbean

Emma Taylor-Salmon; Verity Hill; Lauren M Paul; Robert T Koch; Mallery I Breban; Chrispin Chaguza; Afeez Sodeinde; Joshua L Warren; Sylvia Bunch; Natalia Cano; Marshall Cone; Sarah Eysoldt; Alezaundra Garcia; Nicadia Gilles; Andrew Hagy; Lea Heberlein; Rayah Jaber; Elizabeth Kassens; Pamela Colarusso; Amanda Davis; Samantha Baudin; Edhelene Rico; Álvaro Mejía-Echeverri; Blake Scott; Danielle Stanek; Rebecca Zimler; Jorge L Muñoz-Jordán; Gilberto A Santiago; Laura E Adams; Gabriela Paz-Bailey; Melanie Spillane; Volha Katebi; Robert Paulino-Ramírez; Sayira Mueses; Armando Peguero; Nelissa Sánchez; Francesca F Norman; Juan-Carlos Galán; Ralph Huits; Davidson H Hamer; Chantal B F Vogels; Andrea Morrison; Scott F Michael; Nathan D Grubaugh

doi:10.1038/s41467-024-47774-8

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Travel surveillance uncovers dengue virus dynamics and introductions in the Caribbean

Journal article

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Travel surveillance uncovers dengue virus dynamics and introductions in the Caribbean

Emma Taylor-Salmon, Verity Hill, Lauren M Paul, Robert T Koch, Mallery I Breban, Chrispin Chaguza, Afeez Sodeinde, Joshua L Warren, Sylvia Bunch, Natalia Cano, …

Nature communications, Vol.15(2), pp.314-328

04-25-2024

DOI: https://doi.org/10.1038/s41467-024-47774-8

PMID: 38664380

Appears in United Nations Sustainable Development Goals @ FGCU

Abstract

Caribbean Region - epidemiology

Dengue - epidemiology

Dengue - transmission

Dengue - virology

Dengue Virus - classification

Dengue Virus - genetics

Dengue Virus - isolation & purification

Disease Outbreaks

Epidemiological Monitoring

Humans

Phylogeny

Serogroup

Travel - statistics & numerical data

Dengue is the most prevalent mosquito-borne viral disease in humans, and cases are continuing to rise globally. In particular, islands in the Caribbean have experienced more frequent outbreaks, and all four dengue virus (DENV) serotypes have been reported in the region, leading to hyperendemicity and increased rates of severe disease. However, there is significant variability regarding virus surveillance and reporting between islands, making it difficult to obtain an accurate understanding of the epidemiological patterns in the Caribbean. To investigate this, we used travel surveillance and genomic epidemiology to reconstruct outbreak dynamics, DENV serotype turnover, and patterns of spread within the region from 2009-2022. We uncovered two recent DENV-3 introductions from Asia, one of which resulted in a large outbreak in Cuba, which was previously under-reported. We also show that while outbreaks can be synchronized between islands, they are often caused by different serotypes. Our study highlights the importance of surveillance of infected travelers to provide a snapshot of local introductions and transmission in areas with limited local surveillance and suggests that the recent DENV-3 introductions may pose a major public health threat in the region.

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Title: Travel surveillance uncovers dengue virus dynamics and introductions in the Caribbean
Creators: Emma Taylor-Salmon - Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA. emma.taylor-salmon@yale.edu
Verity Hill - Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA
Lauren M Paul - Department of Biological Sciences, College of Arts and Sciences, Florida Gulf Coast University, Fort Myers, FL, USA
Robert T Koch - Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA
Mallery I Breban - Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA
Chrispin Chaguza - Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA
Afeez Sodeinde - Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA
Joshua L Warren - Public Health Modeling Unit, Yale School of Public Health, New Haven, CT, USA
Sylvia Bunch - Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL, USA
Natalia Cano - Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL, USA
Marshall Cone - Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL, USA
Sarah Eysoldt - Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL, USA
Alezaundra Garcia - Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL, USA
Nicadia Gilles - Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL, USA
Andrew Hagy - Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL, USA
Lea Heberlein - Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL, USA
Rayah Jaber - Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL, USA
Elizabeth Kassens - Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL, USA
Pamela Colarusso - Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Jacksonville, FL, USA
Amanda Davis - Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Jacksonville, FL, USA
Samantha Baudin - Miami Dade College
Edhelene Rico - Miami Dade College
Álvaro Mejía-Echeverri - Miami Dade College
Blake Scott - Bureau of Epidemiology, Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee, FL, USA
Danielle Stanek - Bureau of Epidemiology, Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee, FL, USA
Rebecca Zimler - Bureau of Epidemiology, Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee, FL, USA
Jorge L Muñoz-Jordán - Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico
Gilberto A Santiago - Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico
Laura E Adams - Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico
Gabriela Paz-Bailey - Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico
Melanie Spillane - Bureau for Global Health, United States Agency for International Development, Arlington, VA, USA
Volha Katebi - Office of Data, Analytics, and Technology, Division of Global Migration Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
Robert Paulino-Ramírez - Instituto de Medicina Tropical
Sayira Mueses - Instituto de Medicina Tropical
Armando Peguero - Instituto de Medicina Tropical
Nelissa Sánchez - Instituto de Medicina Tropical
Francesca F Norman - Universidad de Alcalá
Juan-Carlos Galán - Instituto Ramón y Cajal de Investigación Sanitaria
Ralph Huits - Department of Infectious Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy
Davidson H Hamer - Boston University School of Medicine
Chantal B F Vogels - University of New Haven
Andrea Morrison - Bureau of Epidemiology, Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee, FL, USA. andrea.Morrison@flhealth.gov
Scott F Michael - Department of Biological Sciences, College of Arts and Sciences, Florida Gulf Coast University, Fort Myers, FL, USA. smichael@fgcu.edu
Nathan D Grubaugh - University of New Haven
Publication Details: Nature communications, Vol.15(2), pp.314-328
Publisher: Springer Nature; BERLIN
Number of pages: 14
Grant note: DP2AI176740 / Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID)
Identifiers: 99384033964506570
Academic Unit: Department of Biological Sciences
Language: English
Resource Type: Journal article

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Travel surveillance uncovers dengue virus dynamics and introductions in the Caribbean

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