Zika virus evolution and spread in the Americas

Hayden C Metsky; Christian B Matranga; Shirlee Wohl; Stephen F Schaffner; Catherine A Freije; Sarah M Winnicki; Kendra West; James Qu; Mary Lynn Baniecki; Adrianne Gladden-Young; Aaron E Lin; Christopher H Tomkins-Tinch; Simon H Ye; Daniel J Park; Cynthia Y Luo; Kayla G Barnes; Rickey R Shah; Bridget Chak; Giselle Barbosa-Lima; Edson Delatorre; Yasmine R Vieira; Lauren M Paul; Amanda L Tan; Carolyn M Barcellona; Mario C Porcelli; Chalmers Vasquez; Andrew C Cannons; Marshall R Cone; Kelly N Hogan; Edgar W Kopp; Joshua J Anzinger; Kimberly F Garcia; Leda A Parham; Rosa M Gélvez Ramírez; Maria C Miranda Montoya; Diana P Rojas; Catherine M Brown; Scott Hennigan; Brandon Sabina; Sarah Scotland; Karthik Gangavarapu; Nathan D Grubaugh; Glenn Oliveira; Refugio Robles-Sikisaka; Andrew Rambaut; Lee Gehrke; Sandra Smole; M Elizabeth Halloran; Luis Villar; Salim Mattar; Ivette Lorenzana; Jose Cerbino-Neto; Clarissa Valim; Wim Degrave; Patricia T Bozza; Andreas Gnirke; Kristian G Andersen; Sharon Isern; Scott F Michael; Fernando A Bozza; Thiago M L Souza; Irene Bosch; Nathan L Yozwiak; Bronwyn L MacInnis; Pardis C Sabeti

doi:10.1038/nature22402

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Zika virus evolution and spread in the Americas

Journal article

Peer reviewed

Zika virus evolution and spread in the Americas

Hayden C Metsky, Christian B Matranga, Shirlee Wohl, Stephen F Schaffner, Catherine A Freije, Sarah M Winnicki, Kendra West, James Qu, Mary Lynn Baniecki, Adrianne Gladden-Young, …

Nature (London), Vol.546(7658), pp.411-415

06-15-2017

DOI: https://doi.org/10.1038/nature22402

PMCID: PMC5563848

PMID: 28538734

Appears in United Nations Sustainable Development Goals @ FGCU

Abstract

Animals

Brazil - epidemiology

Colombia - epidemiology

Culicidae - virology

Disease Outbreaks - statistics & numerical data

Genome, Viral - genetics

Geographic Mapping

Honduras - epidemiology

Humans

Metagenome - genetics

Mosquito Vectors - virology

Phylogeny

Public Health Surveillance

Puerto Rico - epidemiology

United States - epidemiology

Zika Virus - classification

Zika Virus - genetics

Zika Virus - isolation & purification

Zika Virus - pathogenicity

Zika Virus Infection - diagnosis

Zika Virus Infection - epidemiology

Zika Virus Infection - transmission

Zika Virus Infection - virology

Molecular Epidemiology

Mutation

Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention, much remains unknown about ZIKV disease epidemiology and ZIKV evolution, in part owing to a lack of genomic data. Here we address this gap in knowledge by using multiple sequencing approaches to generate 110 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expanding the observed viral genetic diversity from this outbreak. We analysed the timing and patterns of introductions into distinct geographic regions; our phylogenetic evidence suggests rapid expansion of the outbreak in Brazil and multiple introductions of outbreak strains into Puerto Rico, Honduras, Colombia, other Caribbean islands, and the continental United States. We find that ZIKV circulated undetected in multiple regions for many months before the first locally transmitted cases were confirmed, highlighting the importance of surveillance of viral infections. We identify mutations with possible functional implications for ZIKV biology and pathogenesis, as well as those that might be relevant to the effectiveness of diagnostic tests.

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Title: Zika virus evolution and spread in the Americas
Creators: Hayden C Metsky - Massachusetts Institute of Technology
Christian B Matranga - Broad Institute
Shirlee Wohl - Broad Institute
Stephen F Schaffner - Broad Institute
Catherine A Freije - Broad Institute
Sarah M Winnicki - Broad Institute
Kendra West - Broad Institute
James Qu - Broad Institute
Mary Lynn Baniecki - Broad Institute
Adrianne Gladden-Young - Broad Institute
Aaron E Lin - Broad Institute
Christopher H Tomkins-Tinch - Broad Institute
Simon H Ye - Massachusetts Institute of Technology
Daniel J Park - Broad Institute
Cynthia Y Luo - Broad Institute
Kayla G Barnes - Broad Institute
Rickey R Shah - Broad Institute
Bridget Chak - Broad Institute
Giselle Barbosa-Lima - National Institutes of Health
Edson Delatorre - Fundação Oswaldo Cruz
Yasmine R Vieira - National Institutes of Health
Lauren M Paul - Florida State University
Amanda L Tan - Florida State University
Carolyn M Barcellona - Florida State University
Mario C Porcelli - Miami-Dade County Mosquito Control, Miami, Florida, USA
Chalmers Vasquez - Miami-Dade County Mosquito Control, Miami, Florida, USA
Andrew C Cannons - Florida Department of Health
Marshall R Cone - Florida Department of Health
Kelly N Hogan - Florida Department of Health
Edgar W Kopp - Florida Department of Health
Joshua J Anzinger - University of the West Indies System
Kimberly F Garcia - Universidad Nacional Autónoma de Honduras
Leda A Parham - Universidad Nacional Autónoma de Honduras
Rosa M Gélvez Ramírez - Industrial University of Santander
Maria C Miranda Montoya - Industrial University of Santander
Diana P Rojas - University of Florida
Catherine M Brown - Massachusetts Department of Public Health
Scott Hennigan - Massachusetts Department of Public Health
Brandon Sabina - Massachusetts Department of Public Health
Sarah Scotland - Massachusetts Department of Public Health
Karthik Gangavarapu - Scripps Research Institute
Nathan D Grubaugh - Scripps Research Institute
Glenn Oliveira - Scripps Health
Refugio Robles-Sikisaka - Scripps Research Institute
Andrew Rambaut - University of Edinburgh
Lee Gehrke - Massachusetts Institute of Technology
Sandra Smole - Massachusetts Department of Public Health
M Elizabeth Halloran - University of Washington
Luis Villar - Industrial University of Santander
Salim Mattar - University of Córdoba
Ivette Lorenzana - Universidad Nacional Autónoma de Honduras
Jose Cerbino-Neto - National Institutes of Health
Clarissa Valim - Michigan State University
Wim Degrave - Fundação Oswaldo Cruz
Patricia T Bozza - Fundação Oswaldo Cruz
Andreas Gnirke - Broad Institute
Kristian G Andersen - Scripps Research Institute
Sharon Isern - Florida State University
Scott F Michael - Florida State University
Fernando A Bozza - National Institutes of Health
Thiago M L Souza - Fundação Oswaldo Cruz
Irene Bosch - Massachusetts Institute of Technology
Nathan L Yozwiak - Broad Institute
Bronwyn L MacInnis - Broad Institute
Pardis C Sabeti - Howard Hughes Medical Institute
Publication Details: Nature (London), Vol.546(7658), pp.411-415
Publisher: NATURE PORTFOLIO; BERLIN
Number of pages: 18
Grant note: U19 AI110818 / NIAID NIH HHS R01 AI099210 / NIAID NIH HHS HHSN272201400048C / NIAID NIH HHS R33 AI100190 / NIAID NIH HHS T32 AI007244 / NIAID NIH HHS R21 AI100190 / NIAID NIH HHS UL1 TR001114 / NCATS NIH HHS U54 GM111274 / NIGMS NIH HHS
Identifiers: 99383436520206570
Academic Unit: Department of Biological Sciences
Language: English
Resource Type: Journal article

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Zika virus evolution and spread in the Americas

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UN Sustainable Development Goals (SDGs)