Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort

Betty R Vohr; Roy Heyne; Carla M Bann; Abhik Das; Rosemary D Higgins; Susan R Hintz; Alan H Jobe; Michael S Caplan; Richard A Polin; Abbot R Laptook; Angelita M Hensman; Elisabeth C McGowan; Elisa Vieira; Emilee Little; Katharine Johnson; Barbara Alksninis; Mary Lenore Keszler; Andrea M Knoll; Theresa M Leach; Victoria E Watson; Michele C Walsh; Avroy A Fanaroff; Deanne E Wilson-Costello; Allison Payne; Nancy S Newman; H. Gerry Taylor; Bonnie S Siner; Arlene Zadell; Julie DiFiore; Monika Bhola; Harriet G Friedman; Gulgun Yalcinkaya; Dorothy Bulas; Ronald N Goldberg; C. Michael Cotten; Ricki F Goldstein; Kathryn E Gustafson; Patricia Ashley; Kathy J Auten; Kimberley A Fisher; Katherine A Foy; Sharon F Freedman; Melody B Lohmeyer; William F Malcolm; David K Wallace; David P Carlton; Barbara J Stoll; Ira Adams-Chapman; Susie Buchter; Anthony J Piazza; Carter; Sobha Fritz; Ellen C Hale; Amy K Hutchinson; Maureen Mulligan LaRossa; Yvonne Loggins; Diane Bottcher; Stephanie Wilson Archer; Brenda B Poindexter; Gregory M Sokol; Heidi M Harmon; Lu-Ann Papile; Abbey C Hines; Leslie D Wilson; Dianne E Herron; Lucy Smiley; Kathleen A Kennedy; Jon E Tyson; Andrea Freeman Duncan; Allison G Dempsey; Janice John; Patrick M Jones; M. Layne Lillie; Saba Siddiki; Daniel K Sperry; Mary Anne Berberich; Carol J Blaisdell; Dorothy B Gail; James P Kiley; Dennis Wallace; Marie G Gantz; Jamie E Newman; Jeanette O'Donnell Auman; Jane A Hammond; W. Kenneth Poole; Krisa P Van Meurs; David K Stevenson; Maria Elena DeAnda; M. Bethany Ball; Gabrielle T Goodlin; Ivan D Frantz; John M Fiascone; Anne Furey; Brenda L MacKinnon; Ellen Nylen; Ana Brussa; Cecelia Sibley; Waldemar A Carlo; Namasivayam Ambalavanan; Myriam Peralta-Carcelen; Monica V Collins; Shirley S Cosby; Vivien A Phillips; Kirstin J Bailey; Fred J Biasini; Maria Hopkins; Kristen C Johnston; Kathleen G Nelson; Cryshelle S Patterson; Richard V Rector; Leslie Rodriguez; Amanda Soong; Sally Whitley; Sheree York; Kristy Guest; Leigh Ann Smith; Neil N Finer; Donna Garey; Maynard R Rasmussen; Paul R Wozniak; Yvonne E Vaucher; Martha G Fuller; Natacha Akshoomoff; Wade Rich; Kathy Arnell; Renee Bridge; Edward F Bell; Tarah T Colaizy; John A Widness; Jonathan M Klein; Karen J Johnson; Michael J Acarregui; Diane L Eastman; Tammy L.V Wilgenbusch; Kristi L Watterberg; Robin K Ohls; Janell Fuller; Jean Lowe; Julie Rohr; Conra Backstrom Lacy; Rebecca Montman; Sandra Brown; Pablo J Sánchez; Charles R Rosenfeld; Walid A Salhab; Luc Brion; Sally S Adams; James Allen; Laura Grau; Alicia Guzman; Gaynelle Hensley; Elizabeth T Heyne; Jackie F Hickman; Melissa H Leps; Linda A Madden; Melissa Martin; Nancy A Miller; Janet S Morgan; Araceli Solis; Lizette E Lee; Catherine Twell Boatman; Diana M Vasil; Bradley A Yoder; Roger G Faix; Sarah Winter; Shawna Baker; Karen A Osborne; Carrie A Rau; Sean Cunningham; Ariel Ford; Seetha Shankaran; Athina Pappas; Beena G Sood; Rebecca Bara; Thomas L Slovis; Elizabeth Billian; Laura A Goldston; Mary Johnson; National Institute of Child Health, and Development Neonatal Research Network

doi:10.1016/j.jpeds.2018.04.073

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Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort

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Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort

Betty R Vohr, Roy Heyne, Carla M Bann, Abhik Das, Rosemary D Higgins, Susan R Hintz, Alan H Jobe, Michael S Caplan, Richard A Polin, Abbot R Laptook, …

The Journal of pediatrics, Vol.200, pp.132-139.e3

09-2018

DOI: https://doi.org/10.1016/j.jpeds.2018.04.073

PMCID: PMC6109599

PMID: 29793869

Abstract

hypertension

obese

overweight

preterm

school age

sedentary activity

To identify rates of overweight (body mass index [BMI] ≥85th percentile) and obesity (BMI ≥95th percentile) at 6-7 years of age and associated risk factors among extremely preterm infants born at <28 weeks of gestation. Anthropometrics, blood pressure, and active and sedentary activity levels were prospectively assessed. Three groups were compared, those with a BMI ≥85th percentile (overweight or obese for age, height, and sex) and ≥95th percentile (obese) vs <85th percentile. Multiple regression analyses estimated the relative risks of BMI ≥85th percentile and ≥95th percentile associated with perinatal and early childhood factors. Of 388 children, 22% had a BMI of ≥85th percentile and 10% were obese. Children with obesity and overweight compared with normal weight children had higher body fat (subscapular skinfold and triceps skinfold >85th percentile), central fat (waist circumference >90th percentile), spent more time in sedentary activity (20.5 vs 18.2 vs 16.7 hours/week), and had either systolic and/or diastolic hypertension (24% vs 26% vs 14%), respectively. Postdischarge weight gain velocities from 36 weeks postmenstrual age to 18 months, and 18 months to 6-7 years were independently associated with a BMI of ≥85th percentile, whereas weight gain velocity from 18 months to 6-7 years was associated with obesity. One in 5 former extremely preterm infants is overweight or obese and has central obesity at early school age. Postdischarge weight gain velocities were associated with overweight and obesity. These findings suggest the obesity epidemic is spreading to the most extremely preterm infants. ClinicalTrials.gov: NCT00063063 and NCT0000.

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Title: Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort
Creators: Betty R Vohr - Brown University
Roy Heyne - The University of Texas Southwestern Medical Center
Carla M Bann - RTI International
Abhik Das - RTI International
Rosemary D Higgins - Eunice Kennedy Shriver National Institute of Child Health and Human Development
Susan R Hintz - Stanford University School of Medicine
Alan H Jobe - University of Cincinnati
Michael S Caplan - University of Chicago
Richard A Polin - Columbia University
Abbot R Laptook - Brown University
Angelita M Hensman - Brown University
Elisabeth C McGowan - Brown University
Elisa Vieira - Brown University
Emilee Little - Brown University
Katharine Johnson - Brown University
Barbara Alksninis - Brown University
Mary Lenore Keszler - Brown University
Andrea M Knoll - Brown University
Theresa M Leach - Brown University
Victoria E Watson - Brown University
Michele C Walsh - Case Western Reserve University
Avroy A Fanaroff - Case Western Reserve University
Deanne E Wilson-Costello - Case Western Reserve University
Allison Payne - Case Western Reserve University
Nancy S Newman - Case Western Reserve University
H. Gerry Taylor - Case Western Reserve University
Bonnie S Siner - Case Western Reserve University
Arlene Zadell - Case Western Reserve University
Julie DiFiore - Case Western Reserve University
Monika Bhola - Case Western Reserve University
Harriet G Friedman - Case Western Reserve University
Gulgun Yalcinkaya - Case Western Reserve University
Dorothy Bulas - Department of Diagnostic Imaging and Radiology, Children's National Medical Center, Washington, DC
Ronald N Goldberg - Duke University School of Medicine
C. Michael Cotten - Duke University School of Medicine
Ricki F Goldstein - Duke University School of Medicine
Kathryn E Gustafson - Duke University School of Medicine
Patricia Ashley - Duke University School of Medicine
Kathy J Auten - Duke University School of Medicine
Kimberley A Fisher - Duke University School of Medicine
Katherine A Foy - Duke University School of Medicine
Sharon F Freedman - Duke University School of Medicine
Melody B Lohmeyer - Duke University School of Medicine
William F Malcolm - Duke University School of Medicine
David K Wallace - Duke University School of Medicine
David P Carlton - Emory University
Barbara J Stoll - Emory University
Ira Adams-Chapman - Emory University
Susie Buchter - Emory University
Anthony J Piazza - Emory University
Carter - Emory University
Sobha Fritz - Emory University
Ellen C Hale - Emory University
Amy K Hutchinson - Emory University
Maureen Mulligan LaRossa - Emory University
Yvonne Loggins - Emory University
Diane Bottcher - Emory University
Stephanie Wilson Archer - Eunice Kennedy Shriver National Institute of Child Health and Human Development
Brenda B Poindexter - Indiana University
Gregory M Sokol - Indiana University
Heidi M Harmon - Indiana University
Lu-Ann Papile - Indiana University
Abbey C Hines - Indiana University
Leslie D Wilson - Indiana University
Dianne E Herron - Indiana University
Lucy Smiley - Indiana University
Kathleen A Kennedy - The University of Texas Health Science Center at Houston
Jon E Tyson - The University of Texas Health Science Center at Houston
Andrea Freeman Duncan - The University of Texas Health Science Center at Houston
Allison G Dempsey - The University of Texas Health Science Center at Houston
Janice John - The University of Texas Health Science Center at Houston
Patrick M Jones - The University of Texas Health Science Center at Houston
M. Layne Lillie - The University of Texas Health Science Center at Houston
Saba Siddiki - The University of Texas Health Science Center at Houston
Daniel K Sperry - The University of Texas Health Science Center at Houston
Mary Anne Berberich - National Heart Lung and Blood Institute
Carol J Blaisdell - National Heart Lung and Blood Institute
Dorothy B Gail - National Heart Lung and Blood Institute
James P Kiley - National Heart Lung and Blood Institute
Dennis Wallace - RTI International
Marie G Gantz - RTI International
Jamie E Newman - RTI International
Jeanette O'Donnell Auman - RTI International
Jane A Hammond - RTI International
W. Kenneth Poole - RTI International
Krisa P Van Meurs - Stanford University
David K Stevenson - Stanford University
Maria Elena DeAnda - Stanford University
M. Bethany Ball - Stanford University
Gabrielle T Goodlin - Stanford University
Ivan D Frantz - Tufts Medical Center
John M Fiascone - Tufts Medical Center
Elisabeth C McGowan - Tufts Medical Center
Anne Furey - Tufts Medical Center
Brenda L MacKinnon - Tufts Medical Center
Ellen Nylen - Tufts Medical Center
Ana Brussa - Tufts Medical Center
Cecelia Sibley - Tufts Medical Center
Waldemar A Carlo - University of Alabama at Birmingham
Namasivayam Ambalavanan - University of Alabama at Birmingham
Myriam Peralta-Carcelen - University of Alabama at Birmingham
Monica V Collins - University of Alabama at Birmingham
Shirley S Cosby - University of Alabama at Birmingham
Vivien A Phillips - University of Alabama at Birmingham
Kirstin J Bailey - University of Alabama at Birmingham
Fred J Biasini - University of Alabama at Birmingham
Maria Hopkins - University of Alabama at Birmingham
Kristen C Johnston - University of Alabama at Birmingham
Kathleen G Nelson - University of Alabama at Birmingham
Cryshelle S Patterson - University of Alabama at Birmingham
Richard V Rector - University of Alabama at Birmingham
Leslie Rodriguez - University of Alabama at Birmingham
Amanda Soong - University of Alabama at Birmingham
Sally Whitley - University of Alabama at Birmingham
Sheree York - University of Alabama at Birmingham
Kristy Guest - University of Alabama at Birmingham
Leigh Ann Smith - University of Alabama at Birmingham
Neil N Finer - San Diego Medical Center and Sharp Mary Birch Hospital for Women, University of California
Donna Garey - San Diego Medical Center and Sharp Mary Birch Hospital for Women, University of California
Maynard R Rasmussen - San Diego Medical Center and Sharp Mary Birch Hospital for Women, University of California
Paul R Wozniak - San Diego Medical Center and Sharp Mary Birch Hospital for Women, University of California
Yvonne E Vaucher - San Diego Medical Center and Sharp Mary Birch Hospital for Women, University of California
Martha G Fuller - San Diego Medical Center and Sharp Mary Birch Hospital for Women, University of California
Natacha Akshoomoff - San Diego Medical Center and Sharp Mary Birch Hospital for Women, University of California
Wade Rich - San Diego Medical Center and Sharp Mary Birch Hospital for Women, University of California
Kathy Arnell - San Diego Medical Center and Sharp Mary Birch Hospital for Women, University of California
Renee Bridge - San Diego Medical Center and Sharp Mary Birch Hospital for Women, University of California
Edward F Bell - University of Iowa
Tarah T Colaizy - University of Iowa
John A Widness - University of Iowa
Jonathan M Klein - University of Iowa
Karen J Johnson - University of Iowa
Michael J Acarregui - University of Iowa
Diane L Eastman - University of Iowa
Tammy L.V Wilgenbusch - University of Iowa
Kristi L Watterberg - University of New Mexico
Robin K Ohls - University of New Mexico
Janell Fuller - University of New Mexico
Jean Lowe - University of New Mexico
Julie Rohr - University of New Mexico
Conra Backstrom Lacy - University of New Mexico
Rebecca Montman - University of New Mexico
Sandra Brown - University of New Mexico
Pablo J Sánchez - Parkland Health & Hospital System
Charles R Rosenfeld - Parkland Health & Hospital System
Walid A Salhab - Parkland Health & Hospital System
Luc Brion - Parkland Health & Hospital System
Sally S Adams - Parkland Health & Hospital System
James Allen - Parkland Health & Hospital System
Laura Grau - Parkland Health & Hospital System
Alicia Guzman
Gaynelle Hensley - Parkland Health & Hospital System
Elizabeth T Heyne - Parkland Health & Hospital System
Jackie F Hickman - Parkland Health & Hospital System
Melissa H Leps - Parkland Health & Hospital System
Linda A Madden - Parkland Health & Hospital System
Melissa Martin - Parkland Health & Hospital System
Nancy A Miller - Parkland Health & Hospital System
Janet S Morgan - Parkland Health & Hospital System
Araceli Solis - Parkland Health & Hospital System
Lizette E Lee - Parkland Health & Hospital System
Catherine Twell Boatman - Parkland Health & Hospital System
Diana M Vasil - Parkland Health & Hospital System
Bradley A Yoder - University of Utah
Roger G Faix - University of Utah
Sarah Winter - University of Utah
Shawna Baker - University of Utah
Karen A Osborne - University of Utah
Carrie A Rau - University of Utah
Sean Cunningham - University of Utah
Ariel Ford - University of Utah
Seetha Shankaran - Wayne State University
Athina Pappas - Wayne State University
Beena G Sood - Wayne State University
Rebecca Bara - Wayne State University
Thomas L Slovis - Wayne State University
Elizabeth Billian - Wayne State University
Laura A Goldston - Wayne State University
Mary Johnson - Wayne State University
National Institute of Child Health, and Development Neonatal Research Network
Publication Details: The Journal of pediatrics, Vol.200, pp.132-139.e3
Publisher: Elsevier Inc; NEW YORK
Number of pages: 11
Grant note: National Institutes of Health (https://doi.org/10.13039/100000002) Eunice Kennedy Shriver National Institute of Child Health and Human Development (https://doi.org/10.13039/100009633)
Identifiers: 99383452214606570
Academic Unit: Office of Research & Sponsored Programs
Language: English
Resource Type: Journal article

Extreme Preterm Infant Rates of Overweight and Obesity at School Age in the SUPPORT Neuroimaging and Neurodevelopmental Outcomes Cohort

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