Abstract
Excerpt: There is little dispute that mild therapeutic hypothermia applied in the setting of the randomized trials reduced the frequency of poor outcomes after NE. Unfortunately, it is less clear that it is beneficial in situations with different infrastructures: for example, a small pilot study carried out without access to mechanical ventilation suggested that cooling might increase mortality. Also, we do not know how changes in entry criteria, marked swings in the extent and duration of cooling, adapting different re-warming strategies, prevalence of co-morbidities affecting outcomes, and concurrent therapies (eg, systemic opioids for analgesia) affect outcomes in babies cooled for NE.