Abstract
Excerpt: On September 29, 2021, the Centers for Disease Control and Prevention (CDC) issued an emergency health advisory alerting the health network of the perils of novel coronavirus disease 2019 (COVID-19) during pregnancy.[1] As of September 27, 2021, more than 125,000 pregnant women have been reported to have laboratory-confirmed COVID-19 resulting in 22,000 hospitalizations and 161 deaths.[1] Maternal SARS-CoV-2 infection also increases the risk of adverse neonatal outcomes. In a recent issue of the American Journal of Perinatology, Divekar et al report a preterm infant born to a mother with an acute severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection presenting with features similar to multisystem inflammatory syndrome in children (MIS-C). This article reviews various case reports on neonatal COVID-19 focusing on controversies in the diagnosis of MIS-C in the neonatal period.