Prolonged duration of early antibiotic therapy in extremely premature infants

Rachel G. Greenberg; Dhuly Chowdhury; Nellie Hansen; P. Brian Smith; Barbara J. Stoll; Pablo J. Sanchez; Abhik Das; Karen M. Puopolo; Sagori Mukhopadhyay; Rosemary D. Higgins; C. Michael Cotten; Michael S. Caplan; Richard A. Polin; Abbot R. Laptook; Martin Keszler; Angelita M. Hensman; Kristin M. Basso; Elisa Vieira; Emily Little; Michele C. Walsh; Avroy A. Fanaroff; Anna Marie Hibbs; Nancy S. Newman; Bonnie S. Siner; William E. Truog; Howard W. Kilbride; Eugenia K. Pallotto; Cheri Gauldin; Anne Holmes; Kathy Johnson; Allison Knutson; Brenda B. Poindexter; Kurt Schibler; Barbara Alexander; Cathy Grisby; Lenora D. Jackson; Kristin Kirker; Greg Muthig; Ronald N. Goldberg; Kimberley A. Fisher; Sandra Grimes; Joanne Finkle; Matthew M. Laughon; Carl L. Bose; Janice Bernhardt; Gennie Bose; David P. Carlton; Ellen C. Hale; Ann Blackwelder; Yvonne C. Loggins; Diane Bottcher; Stephanie Wilson Archer; Gregory M. Sokol; Leslie Dawn Wilson; Dianne E. Herron; Kathleen A. Kennedy; Jon E. Tyson; Julie Arldt-McAlister; Katrina Burson; Carmen Garcia; Beverly Foley Harris; Karen Martin; Sara C. Martin; Georgia E. McDavid; Shawna Rodgers; Patti L. Pierce Tate; Sharon L. Wright; Leif D. Nelin; Sudarshan R. Jadcherla; Patricia Luzader; Christine A. Fortney; Gail E. Besner; Nehal A. Parikh; Dennis Wallace; Marie G. Gantz; Jeanette O'Donnell Auman; Margaret M. Crawford; Jenna Gabrio; Carolyn M. Petrie Huitema; Kristin M. Zaterka-Baxter; Krisa P. Van Meurs; Marian M. Adams; David K. Stevenson; M. Bethany Ball; Andrew W. Palmquist; Melinda S. Proud; Ivan D. Frantz; John M. Fiascone; Brenda L. MacKinnon; Ellen Nylen; Waldemar A. Carlo; Namasivayam Ambalavanan; Monica Collins; Shirley S. Cosby; Uday Devaskar; Meena Garg; Teresa Chanlaw; Rachel Geller; Edward F. Bell; Dan L. Ellsbury; Eunice Kennedy Shriver Natl Inst C

doi:10.1038/s41390-019-0300-4

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Prolonged duration of early antibiotic therapy in extremely premature infants

Journal article

Peer reviewed

Prolonged duration of early antibiotic therapy in extremely premature infants

Rachel G. Greenberg, Dhuly Chowdhury, Nellie Hansen, P. Brian Smith, Barbara J. Stoll, Pablo J. Sanchez, Abhik Das, Karen M. Puopolo, Sagori Mukhopadhyay, Rosemary D. Higgins, …

Pediatric research, Vol.85(7), pp.994-1000

01-22-2019

DOI: https://doi.org/10.1038/s41390-019-0300-4

PMID: 30737489

Abstract

Life Sciences & Biomedicine

Science & Technology

Pediatrics

BACKGROUND: Prolonged early antibiotics in extremely premature infants may have negative effects. We aimed to assess prevalence and outcomes of provision of prolonged early antibiotics to extremely premature infants in the absence of culture-confirmed infection or NEC. METHODS: Cohort study of infants from 13 centers born without a major birth defect from 2008-2014 who were 401-1000 grams birth weight, 22-28 weeks gestation, and survived >= 5 days without culture-confirmed infection, NEC, or spontaneous intestinal perforation. We determined the proportion of infants who received prolonged early antibiotics, defined as >= 5 days of antibiotic therapy started at <= 72 h of age, by center and over time. Associations between prolonged early antibiotics and adverse outcomes were assessed using multivariable logistic regression. RESULTS: A total of 5730 infants were included. The proportion of infants receiving prolonged early antibiotics varied from 30-69% among centers and declined from 49% in 2008 to 35% in 2014. Prolonged early antibiotics was not significantly associated with death (adjusted odds ratio 1.17 [95% CI: 0.99-1.40], p = 0.07) and was not associated with NEC. CONCLUSIONS: The proportion of extremely premature infants receiving prolonged early antibiotics decreased, but significant center variation persists. Prolonged early antibiotics were not significantly associated with increased odds of death or NEC.

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Title: Prolonged duration of early antibiotic therapy in extremely premature infants
Creators: Rachel G. Greenberg - Duke University
Dhuly Chowdhury - RTI Int, Social Stat & Environm Sci Unit, Res Triangle Pk, NC USA
Nellie Hansen - RTI Int, Social Stat & Environm Sci Unit, Res Triangle Pk, NC USA
P. Brian Smith - Duke University
Barbara J. Stoll - Supreme Council Of Health
Pablo J. Sanchez - Nationwide Childrens Hosp, Dept Pediat, Columbus, OH USA
Abhik Das - RTI Int, Social Stat & Environm Sci Unit, Rockville, MD USA
Karen M. Puopolo - Supreme Council Of Health
Sagori Mukhopadhyay - Supreme Council Of Health
Rosemary D. Higgins - Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA
C. Michael Cotten - Duke University
Michael S. Caplan - University of Chicago
Richard A. Polin - Columbia University
Abbot R. Laptook - Brown University
Martin Keszler - Brown University
Angelita M. Hensman - Brown University
Kristin M. Basso - Brown University
Elisa Vieira - Brown University
Emily Little - Brown University
Michele C. Walsh - Case Western Reserve University
Avroy A. Fanaroff - Case Western Reserve University
Anna Marie Hibbs - Case Western Reserve University
Nancy S. Newman - Case Western Reserve University
Bonnie S. Siner - Case Western Reserve University
William E. Truog - University of Missouri
Howard W. Kilbride - University of Missouri
Eugenia K. Pallotto - University of Missouri
Cheri Gauldin - University of Missouri
Anne Holmes - University of Missouri
Kathy Johnson - University of Missouri
Allison Knutson - University of Missouri
Brenda B. Poindexter - College Station Medical Center
Kurt Schibler - College Station Medical Center
Barbara Alexander - College Station Medical Center
Cathy Grisby - College Station Medical Center
Lenora D. Jackson - College Station Medical Center
Kristin Kirker - College Station Medical Center
Greg Muthig - College Station Medical Center
Ronald N. Goldberg - Duke University
Kimberley A. Fisher - Duke University
Sandra Grimes - Duke University
Joanne Finkle - Duke University
Matthew M. Laughon - Duke University
Carl L. Bose - Duke University
Janice Bernhardt - Duke University
Gennie Bose - Duke University
David P. Carlton - Emory University
Ellen C. Hale - Emory University
Ann Blackwelder - Emory University
Yvonne C. Loggins - Emory University
Diane Bottcher - Emory University
Stephanie Wilson Archer - Emory University
Gregory M. Sokol - Indiana University
Leslie Dawn Wilson - Indiana University
Dianne E. Herron - Indiana University
Kathleen A. Kennedy - Supreme Council Of Health
Jon E. Tyson - Supreme Council Of Health
Julie Arldt-McAlister - Supreme Council Of Health
Katrina Burson - Supreme Council Of Health
Carmen Garcia - Supreme Council Of Health
Beverly Foley Harris - Supreme Council Of Health
Karen Martin - Supreme Council Of Health
Sara C. Martin - Supreme Council Of Health
Georgia E. McDavid - Supreme Council Of Health
Shawna Rodgers - Supreme Council Of Health
Patti L. Pierce Tate - Supreme Council Of Health
Sharon L. Wright - Supreme Council Of Health
Leif D. Nelin - Nationwide Childrens Hosp, Columbus, OH USA
Sudarshan R. Jadcherla - Nationwide Childrens Hosp, Columbus, OH USA
Patricia Luzader - Nationwide Childrens Hosp, Columbus, OH USA
Christine A. Fortney - Nationwide Childrens Hosp, Columbus, OH USA
Gail E. Besner - Nationwide Childrens Hosp, Columbus, OH USA
Nehal A. Parikh - Nationwide Childrens Hosp, Columbus, OH USA
Dennis Wallace - RTI (United States)
Marie G. Gantz - RTI (United States)
Jeanette O'Donnell Auman - RTI Int, Res Triangle Pk, NC USA
Margaret M. Crawford - RTI (United States)
Jenna Gabrio - RTI (United States)
Carolyn M. Petrie Huitema - RTI Int, Res Triangle Pk, NC USA
Kristin M. Zaterka-Baxter - RTI (United States)
Krisa P. Van Meurs - Stanford University
Marian M. Adams - Stanford University
David K. Stevenson - Stanford University
M. Bethany Ball - Stanford University
Andrew W. Palmquist - Stanford University
Melinda S. Proud - Stanford University
Ivan D. Frantz - College Station Medical Center
John M. Fiascone - College Station Medical Center
Brenda L. MacKinnon - College Station Medical Center
Ellen Nylen - College Station Medical Center
Waldemar A. Carlo - University of Alabama
Namasivayam Ambalavanan - University of Alabama
Monica Collins - University of Alabama
Shirley S. Cosby - University of Alabama
Uday Devaskar - Mattel (United States)
Meena Garg - Mattel (United States)
Teresa Chanlaw - Mattel (United States)
Rachel Geller - Mattel (United States)
Edward F. Bell - University of Iowa
Dan L. Ellsbury - University of Iowa
Eunice Kennedy Shriver Natl Inst C
Publication Details: Pediatric research, Vol.85(7), pp.994-1000
Publisher: Springer Nature
Number of pages: 7
Grant note: University of Rochester Medical Center, Golisano Children's Hospital U10 HD53089; UL1 TR41 / University of New Mexico Health Sciences Center MSN RNC-NIC U10 HD27856; M01 RR750; UL1 TR6 / Wishard Health Services University of Texas Southwestern Medical Center at Dallas University of Pennsylvania, Hospital of the University of Pennsylvania, Pennsylvania Hospital U10 HD34216; M01 RR32; RN BSN MaEd / University of Alabama at Birmingham Health System and Children's Hospital of Alabama BSN RNC-NIC U10 HD21373; RN BSN / McGovern Medical School at The University of Texas Health Science Center at Houston, Children's Memorial Hermann Hospital U10 HD68263; M01 RR44; UL1 TR42 / University of Buffalo Women's and Children's Hospital of Buffalo
Identifiers: 99385550122006570
Academic Unit: Office of Research & Sponsored Programs
Language: English
Resource Type: Journal article

Prolonged duration of early antibiotic therapy in extremely premature infants

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